The thyroid is an endocrine gland in the neck that produces two thyroid hormones - triiodothyronine (T3) and thyroxine (T4), and calcitonin.
 
Thyroid hormones control the metabolism of almost every cell in the body, with wide-ranging metabolic, developmental and cardiovascular effects.
 
Imbalance can result in HPT axis (Hypothalamus-Pituitary-Thyroid) dysfunction, autoimmune thyroid diseases (AITDs) such as Graves’ and Hashimoto’s, thyroid sensitive cancers (although rare), and impact transport, activation and response to thyroid hormones.
 
GENES INCLUDED
HPT Axis: CAPZB, FKBP5, GPX1*, PDE8B, TG*, TSHR* (*also involved in autoimmunity)
Autoimmune: CTLA4, FOXE1, HLA-DQA1, HLA-DQB1 and PTPN22
Inflammation: CD40, FCRL3, IL6, TNF, GC and VDR
Transport: SLCO1B1 and SLCO1C1
Activation: DIO1, DIO2, BCO1, GC and VDR
Metabolism: SULT1A1, SULT1E1, UGT1A1
 
 
 
Two other reports are also available APOE and detoxification.